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The participant must be at least 18 years old and: Have a BMI of 35 or greater, or Have a BMI of 30 or greater with a diagnosis of diastolic heart failure, uncontrolled hypertension or chronic kidney disease Stage 3a or higher, or Have a BMI of 27 or greater with pre-diabetes, previous myocardial infarction or stroke, or symptomatic peripheral artery disease

Water retention is risky, as it contributes to major discomfort with mobility and is associated with serious health conditions such as cardiovascular failure, malignant lymphedema, or kidney disease

Tirzepatide's dual mechanismactivating both GLP-1 and GIP receptorsmay provide more consistent appetite suppression in post-cholecystectomy patients compared to single-receptor agonists

Avoid stimulating activities during the wind-down period, including work emails, social media, news, intense exercise, and emotionally charged conversations

10.1016/j.cbi.2016.02.017 Chem